General Science

Human Physiology, Diseases & Vaccines

Bacterial, viral, fungal, protozoan diseases, immune response, mRNA vaccines, and AMR.

Target: EPFO APFC 2026Topic-Level RAG Context ActiveModel: Nemotron 3.5 Lightning 30B / 120B

Topic Overview

Bacterial, viral, fungal, protozoan diseases, immune response, mRNA vaccines, and AMR.

Key Syllabus Concepts

  • Pathogens: Viruses (Dengue, Rabies, HIV, Hepatitis), Bacteria (TB, Cholera, Typhoid), Protozoa (Malaria)
  • Immune System: Innate vs Adaptive Immunity, Antibodies (IgG, IgM, IgA), T-cells and B-cells
  • Vaccine Platforms: Inactivated, Live-attenuated, Viral Vector (Covishield), mRNA (Pfizer/Moderna), Protein subunit
  • Antimicrobial Resistance (AMR), Superbugs, and WHO Priority Pathogens

High-Yield Important Points & Rules

  • 💡 Malaria is caused by Plasmodium protozoa transmitted by female Anopheles mosquitoes.
  • 💡 mRNA vaccines do NOT alter host DNA; they deliver instructions for cells to make the spike protein temporarily.

Historical UPSC EPFO PYQ Relevance

3 Matched PYQs
2023EPFO EO/AOGeneral Ability Test• Q.92
Full Question
Which of the following is/are elements of India's 'Panchamrit' view on climate change?
1
India will reach its non-fossil energy capacity of 500 GW by 2030.
2
India will meet 50% of its energy requirements from renewable energy by 2030.
2021EPFO EO/AOGeneral Ability Test• Q.45
Full Question
The word 'Vaccine' has been derived from a Latin word having meaning
2021EPFO EO/AOGeneral Ability Test• Q.104
Full Question
Under Sukanya Samriddhi Yojana, what is the maximum amount that can be deposited during a financial year?

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